Avisford Nature Reserve protects areas of relatively high ridgelands typified by steep sloping gullies and hills with open forest and woodlands. These ridgelands provide habitat for diverse fauna and flora populations. The Reserve contains the Capertee stringybark, a tree with a limited geographical range, and seven animal species listed as vulnerable under the Threatened Species Conservation Act 1995.
Avisford Nature Reserve also provides a naturally vegetated backdrop to Mudgee, and contains a small number of Aboriginal sites.