Clarence Estuary Nature Reserve protects a small remnant of the Clarence estuary foreshore. It contains a high diversity of plant species, including an area of saltmarsh, which provides significant habitat for a range of native animals. These include at least 30 listed migratory species, some of which are also listed as threatened under the Threatened Species Conservation Act 1995.
Clarence Estuary Nature Reserve also contains areas that are of significance to the Yaegl Aboriginal people who have had a continuing connection to the land since pre-European times.