Kirramingly Nature Reserve is of very high conservation value as it contains the only reserved representative example of the once widespread Mitchell grass / Queensland Bluegrass community that occurred across the north west plains of NSW. The reserve contains populations of Desmodium campylocaulon and Swainsona murrayana which are listed as Endangered and Vulnerable, respectively, under the Threatened Species Conservation Act 1995.
Queensland Bluegrass dominant grasslands within the Brigalow Belt Bioregions (North and South) are listed as an Endangered Ecological Community under the Commonwealth Environmental Protection and Biodiversity Conservation Act 1999.
Kirramingly Nature Reserve also contains a cluster of scarred trees which are of significance to the Kamileroi Aboriginal nation.